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Which statement about the laboratory value GFR is FALSE?

  1. GFR stands for glomerular filtration rate

  2. GFR is calculated from BUN test results

  3. GFR estimates blood flow through kidney glomeruli

  4. GFR measures kidney function and disease severity

The correct answer is: GFR is calculated from BUN test results

The statement that GFR is calculated from BUN test results is misleading and therefore the correct answer. The Glomerular Filtration Rate (GFR) is a crucial indicator of kidney function, primarily calculated using serum creatinine levels combined with factors such as age, sex, and race, through equations like the Modified Diet in Renal Disease (MDRD) or the Cockcroft-Gault formula. While Blood Urea Nitrogen (BUN) levels can provide supportive information regarding kidney function, GFR is not directly derived from BUN. Instead, BUN can be influenced by various factors unrelated to kidney function, such as hydration status or protein intake, making it an unreliable sole indicator for calculating GFR. The other statements are accurate: GFR stands for glomerular filtration rate, which emphasizes its role in reflecting kidney performance; it does indeed estimate blood flow through the kidney glomeruli, reflecting how effectively the kidneys filter waste from the blood; and GFR is a critical metric used to assess overall kidney function and the severity of kidney disease.